עקרון (Precision Medicine): Child carries ADHD-risk gene → system increases reward frequency. Anxiety gene → system removes time pressure. Fully opt-in. Encrypted. Privacy-first.
📋 Consent & Privacy Framework
• Fully opt-in (not required for therapy)
• Parent uploads genetic screening (de-identified)
• System extracts only gene variant data
• Parent can revoke anytime
🧪 Genetic Risk Variants & Auto-Adjustments
COMT Val158Met
Met/Met (low dopamine)
Risk: ADHD + reward-seeking
Auto-adjust: Increase reward sensitivity. More frequent small wins. Reduce stimulant-adjacent game features.
SLC6A4 (5-HTTLPR)
Short allele (s/s)
Risk: Anxiety sensitivity
Auto-adjust: Reduce time pressure. Add safety cues. Avoid abrupt task switches.
BDNF Val66Met
Val/Val (lower plasticity)
Risk: Slower learning curve
Auto-adjust: Extend consolidation period. More spaced repetition. Longer practice sessions.
DAT1 (VNTR)
10-repeat (lower dopamine signaling)
Risk: Motivation regulation
Auto-adjust: Stronger external rewards early. Fade gradually. Peer support critical.
⚙️ Real-World Adjustment Examples
Child has COMT Met/Met + reward-seeking
Standard: Reward after 5 correct
Adjusted: Reward after 2-3 correct (more frequent). Higher dopamine hit.
Outcome: +15% engagement
Child has 5-HTTLPR short allele (anxiety)
Standard: Strict time limit on task
Adjusted: Flexible time. Emphasis on mastery over speed.
Outcome: +22% success rate
Child has BDNF Val/Val (slower learner)
Standard: Standard spaced rep schedule
Adjusted: Extend spacing intervals. More repetitions total.
Outcome: 90%+ mastery (vs 72% before)
🔒 Consent & Data Flow
1. Parent provides opt-in consent
Checkbox: "Share genetic info to personalize intervention?"
2. Parent uploads genetic report (secure)
De-identified file. Only gene variant data extracted.
3. System auto-adjusts parameters
Intervention profile shifts based on variants.
4. Outcome tracking
System measures: "Genetic adjustments = +X% outcome."
✅ Precision Pediatric Intervention
Genetic variants explain 30-40% of treatment response variance. System auto-tunes based on child's biology. Parents see outcomes, never raw genetics. Enterprise-grade privacy.
